hrp0097p1-142 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Stimulated copeptin based diagnosis of central diabetes insipidus in children and adolescents

Gippert Sebastian , Choukair Daniela , Brune Maik , Bettendorf Markus

Introduction: Diagnosis of central diabetes insipidus (CDI) remains challenging. Water deprivation test and hypertonic saline infusion, as established diagnostic tests, are mentally and physically demanding for patients. Copeptin response to arginine-stimulation and insulin tolerance test (ITT) has been shown to be a putative parameter in the diagnosis of CDI in adults, but data are lacking for children and adolescents.Methods:</...